<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vguit</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник Воронежского государственного университета инженерных технологий</journal-title><trans-title-group xml:lang="en"><trans-title>Proceedings of the Voronezh State University of Engineering Technologies</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2226-910X</issn><issn pub-type="epub">2310-1202</issn><publisher><publisher-name>VSUET</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20914/2310-1202-2023-2-151-155</article-id><article-id custom-type="elpub" pub-id-type="custom">vguit-2861</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Пищевая  биотехнология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Food biotechnology</subject></subj-group></article-categories><title-group><article-title>Инновационные перспективы создания биологически активных комплексов на основе полисахаридной матрицы</article-title><trans-title-group xml:lang="en"><trans-title>Innovative prospects for the creation of biologically active complexes based on a polysaccharide matrix</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шелепов</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Shelepov</surname><given-names>V. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>член-корреспондент РАН, д.с-х.н., профессор, главный научный сотрудник, лаборатория продуктов функционального питания, ул. Центральная, Президиум, п. Краснообск, 633501, Россия</p></bio><bio xml:lang="en"><p>corresponding member of RAS, Dr. Sci. (Agric.), professor, chief researcher, laboratory of functional nutrition products, Tsentralnaya St., Presidium, Krasnobsk settlement, 633501, Russia,</p></bio><email xlink:type="simple">vshelepov@ya.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бямбаа</surname><given-names>Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Byambaa</surname><given-names>Badarch</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.вет.н., президент, 11-ый Xороо, Зайсан, Хан-уул район, г. Улан-Батор, 17024, Монголия</p></bio><bio xml:lang="en"><p>Dr. Sci. (Vet.), president, 11th Khoroo, Zaisan, Khan Uul District, Ulaanbaatar, 17024, Mongolia</p></bio><email xlink:type="simple">noreplay@elpub.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Челнакова</surname><given-names>Н. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Chelnakova</surname><given-names>N. G.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Позняковский</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Pozniakovsky</surname><given-names>V. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>профессор, кафедра Гигиены, ул. Ворошилова 22А, г. Кемерово, 650021, Россия</p></bio><bio xml:lang="en"><p>professor, hygiene department, 22A Voroshilova St., Kemerovo, 650021, Russia</p></bio><email xlink:type="simple">pvm1947@bk.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Сибирский федеральный научный центр агробиотехнологий РАН</institution></aff><aff xml:lang="en"><institution>Siberian Federal Research Center for Agrobiotechnology RAS</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Монгольская академия аграрных наук</institution></aff><aff xml:lang="en"><institution>Mongolian Academy of Agrarian Sciences</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Артлайф</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Artlife</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Кемеровский государственный медицинский университет</institution><country>Russian Federation</country></aff><aff xml:lang="en"><institution>Kemerovo State Medical University,</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>26</day><month>10</month><year>2023</year></pub-date><volume>85</volume><issue>2</issue><fpage>151</fpage><lpage>155</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шелепов В.Г., Бямбаа Б., Челнакова Н.Г., Позняковский В.М., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Шелепов В.Г., Бямбаа Б., Челнакова Н.Г., Позняковский В.М.</copyright-holder><copyright-holder xml:lang="en">Shelepov V.G., Byambaa B., Chelnakova N.G., Pozniakovsky V.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.vestnik-vsuet.ru/vguit/article/view/2861">https://www.vestnik-vsuet.ru/vguit/article/view/2861</self-uri><abstract><p>Рассматривается возможность соединения сложнорастворимых полисахаридов арабиногалактана с полисахаридами хитозана для повышения всасываемости биологически активных веществ и соединений, характеризующихся низкой биодоступностью. Входящие в состав биологически активной биополимерной матрицы сукцинат хитозана, янтарный ангидрит, арабиногалактан и дигидрокверцитин соответственно в количествах, мас. %: 3–5,0; 2,0–4,0; 15,0–20,0 и 3,5 могут служить целенаправленным носителем для доставки диагностических и терапевтических агентов, в том числе ферментов, нуклеиновых кислот, витаминов, гормонов и др. к определенным клеткам, в частности, гепатоцитам (паренхимным клеткам печени). Установлена высокая мембранотропность арабиногалактана, выделенного из лиственницы, что позволяет его использовать для повышения всасываемости в желудочно-кишечном тракте других функционально-активных ингредиентов с низкой биодоступностью. Механизм такого действия связан с образованием связующего комплекса между арабиногалактаном и доставляемым агентом, обладающим способностью взаимодействовать с асиалогликопротеиновым рецептором клетки. Выполнены исследования по возможности соединения полисахаридов арабиногалактана с полисахаридами хитозана с получением биополимерной матрицы, которая включает сукцинат хитозана, янтарный ангидрид и арабиногалактан, содержащий ковалентно не связанный с ним дигидрокверцетин. Наряду с вышеуказанными свойствами показана эффективность применения арабиногалактана на примере его применения для улучшения технологических и функциональных характеристик мяса цыплят-бройлеров с признаками PSE. Добавление арабиногалактана в рецептурный состав фарша при производстве колбас, в количестве 0,5% от основного сырья, повышало влагосвязывающую способность на 5% при снижении потерь при тепловой обработке на 6%. Отмечено улучшение пероксидного и кислотного чисел при хранении, что обеспечивает ингибирование окислительных процессов и предотвращает порчу готовой продукции.</p></abstract><trans-abstract xml:lang="en"><p>The possibility of combining complexly soluble arabinogalactan polysaccharides with chitosan polysaccharides to increase the absorption of biologically active substances and compounds characterized by low bioavailability is being considered. Included in the biologically active biopolymer matrix are chitosan succinate, succinic anhydrite, arabinogalactan and dihydroquercetin, respectively, in quantities, wt. %: 3–5.0; 2.0–4.0; 15.0–20.0 and 3.5 can serve as a targeted carrier for the delivery of diagnostic and therapeutic agents, including enzymes, nucleic acids, vitamins, hormones, etc. to certain cells, in particular, hepatocytes (liver parenchyma cells). The high membranotropic properties of arabinogalactan isolated from larch have been established, which allows its use to increase the absorption in the gastrointestinal tract of other functionally active ingredients with low bioavailability. The mechanism of this action is associated with the formation of a binding complex between arabinogalactan and the delivered agent, which has the ability to interact with the asialoglycoprotein cell receptor. Studies have been carried out on the possibility of combining arabinogalactan polysaccharides with chitosan polysaccharides to obtain a biopolymer matrix, which includes chitosan succinate, succinic anhydride and arabinogalactan containing dihydroquercetin not covalently bound to it. Along with the above properties, the effectiveness of using arabinogalactan is shown using the example of its use to improve the technological and functional characteristics of broiler chicken meat with PSE traits. The addition of arabinogalactan to the recipe composition of minced meat during the production of sausages, in an amount of 0.5% of the main raw material, increased the moisture-binding capacity by 5% while reducing losses during heat treatment by 6%. There was an improvement in peroxide and acid numbers during storage, which ensures inhibition of oxidative processes and prevents spoilage of finished products.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>арабиногалактан</kwd><kwd>сукцинат хитозана</kwd><kwd>биокомплекс</kwd><kwd>биологически активные соединения</kwd><kwd>полисахариды</kwd></kwd-group><kwd-group xml:lang="en"><kwd>arabinogalactan</kwd><kwd>chitosan succinate</kwd><kwd>biocomplex</kwd><kwd>biologically active compounds</kwd><kwd>polysaccharides</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Антонова Г.Ф., Тюкавкина Н.А. Получение высокочистого арабиногалактана из древесины лиственницы // Химия древесины. 1976. № 4. С. 60–62.</mixed-citation><mixed-citation xml:lang="en">Antonova G.F., Tyukavkina N.A. Preparation of high-purity arabinogalactan from larch wood. Chemistry of wood. 1976. no. 4. pp. 60–62. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Арифходжаев А.О. Галактаны и галактансодержащие полисахариды высших растений // Химия природных соединений. 2000. № 3. С. 185–197.</mixed-citation><mixed-citation xml:lang="en">Arifkhodzhaev A.O. Galactans and galactan-containing polysaccharides of higher plants. Chemistry of natural compounds. 2000. no. 3. pp. 185–197. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Бабкин В.А., Остроухова Л.А., Малков Ю.А., Иванова С.З. и др. Биологически активные вещества из древесины лиственницы // Химия в интересах устойчивого развития. 2001. Т. 9, № 3. С. 363–367.</mixed-citation><mixed-citation xml:lang="en">Babkin V.A., Ostroukhova L.A., Malkov Yu.A., Ivanova S.Z. et al. Biologically active substances from larch wood. Chemistry for sustainable development. 2001. vol. 9. no. 3. pp. 363–367. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Гришин А.А. Хитин и хитозан: Химия, биологическая активность, применение // Известия вузов. Прикладная химия и биотехнология. 2014. Т.6. № 1. С. 29–34.</mixed-citation><mixed-citation xml:lang="en">Grishin A.A. Chitin and chitosan: Chemistry, biological activity, application. News of universities. Applied chemistry and biotechnology. 2014. vol. 6. no. 1. pp. 29–34. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Оводов Ю.С. Полисахариды цветковых растений: структура и физиологическая активность // Биоорганическая химия. 1998. Т. 24. № 7. С. 483–501.</mixed-citation><mixed-citation xml:lang="en">Ovodov Yu.S. Polysaccharides of flowering plants: structure and physiological activity. Bioorganic chemistry. 1998. vol. 24. no. 7. pp. 483–501. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Васюкова А.Т., Славянский А.А., Хайрулин М.Ф., Алексеев А.Е., Мошкин А.В. и др. Продукты с растительными добавками для здорового питания // Пищевая промышленность. 2019. №. 12. С. 72-75.</mixed-citation><mixed-citation xml:lang="en">Vasyukova A.T., Slavyansky A.A., Khairulin M.F., Alekseev A.E., Moshkin A.V. et al. Products with herbal additives for a healthy diet. Food industry. 2019. no. 12. pp. 72-75. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Фазилова С.А., Югай С.М., Рашидова С.Ш. Структурные исследования полисахаридов и нанокомпозиций на их основе // Химия растительного сырья. 2010. № 1. С. 13–19.</mixed-citation><mixed-citation xml:lang="en">Fazilova S.A., Yugai S.M., Rashidova S.Sh. Structural studies of polysaccharides and nanocompositions based on them. Chemistry of plant raw materials. 2010. no. 1. pp. 13–19. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Пат. № 2698455, RU, A61K 31/352, 31/715, 47/36, 47/12, 9/00. Биополимеиная матрица на основе сукцината хитозана, арабиногалактана и способ её получения / Шелепов В.Г., Углов В.А., Душкин А.В., Сунцова Л.П. и др. № 2018141734; Заявл. 26.11.2018; Опубл. 27.08.2019.</mixed-citation><mixed-citation xml:lang="en">Shelepov V.G., Uglov V.A., Dushkin A.V., Suntsova L.P. et al. Biopolymein matrix based on chitosan succinate, arabinogalactan and method of its preparation. Patent RF, no. 2698455, 2019.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Макеева И., Пряничникова Н.С., Богатырев А.Н. Научные походы к выбору нетрадиционных ингредиентов для создания функциональных продуктов животного происхождения, в том числе органических // Пищевая промышленность. 2016. №. 3. С. 34-37.</mixed-citation><mixed-citation xml:lang="en">Makeeva I., Pryanichnikova N.S., Bogatyrev A.N. Scientific approaches to the selection of non-traditional ingredients for the creation of functional products of animal origin, including organic ones. Food industry. 2016. no. 3. pp. 34-37. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Assam T., Eliyahu H., Shapira L., Linial M. et al. Polysaccharide-oligoamine based conjugates for gene delivery // Journal Med. Chem. 2002. V. 45. №. 9. P. 1817–1824.</mixed-citation><mixed-citation xml:lang="en">Assam T., Eliyahu H., Shapira L., Linial M. et al. Polysaccharide-oligoamine based conjugates for gene delivery. Journal Med. Chem. 2002. vol. 45. no. 9. pp. 1817–1824.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Chintalwar G., Jain A., Sipahimalani A., Banerji A. et al. An immunologically active arabinogalactan from Tinospora cordifolia // Phytochemistry. 1999. V. 52. №. 6. P.1089–1093.</mixed-citation><mixed-citation xml:lang="en">Chintalwar G., Jain A., Sipahimalani A., Banerji A. et al. An immunologically active arabinogalactan from Tinospora cordifolia. Phytochemistry. 1999. vol. 52. no. 6. pp.1089–1093.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Pat. № 6406686, US, A61K8/463. Conditioning shampoo containing arabinogalactan / Chun Ho-Ming. Appl. 21.03.2000; Publ. 18.06. 2002.</mixed-citation><mixed-citation xml:lang="en">Chun Ho-Ming. Conditioning shampoo containing arabinogalactan. Patent US, no. 6406686, 2002.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Silva B.P., Parente J.P. Chemical properties and biological activity of a polysaccharide from Melocactus depressus // Planta Medica. 2002. V. 68. №. 1. P. 74–76.</mixed-citation><mixed-citation xml:lang="en">Silva B.P., Parente J.P. Chemical properties and biological activity of a polysaccharide from Melocactus depressus. Planta Medica. 2002. vol. 68. no. 1. pp. 74–76.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Pat. № 3509126, US, C08B37/006. Recovery of high-purity arabinogalactan from larch / Dahl K. Appl. 07.09.1967; Publ. 28.04.1970.</mixed-citation><mixed-citation xml:lang="en">Dahl K. Recovery of high-purity arabinogalactan from larch. Patent US, no. 3509126, 1970.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Clarcke A.E., Anderson R.L., Stone B.A. Form and function of arabinogalactans and arabinogalactan-proteins // Phytochemistry. 1979. V. 18. P.521–540.</mixed-citation><mixed-citation xml:lang="en">Clarcke A.E., Anderson R.L., Stone B.A. Form and function of arabinogalactans and arabinogalactan-proteins. Phytochemistry. 1979. vol. 18. pp.521–540.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Da Silva B.P., Parente J.P. Chemical properties and biological activity of a polysaccharide from Melocactus depressus // Planta Medica. 2002. V. 68. №. 1. P. 74–76.</mixed-citation><mixed-citation xml:lang="en">Da Silva B.P., Parente J.P. Chemical properties and biological activity of a polysaccharide from Melocactus depressus. Planta Medica. 2002. vol. 68. no. 1. pp. 74–76.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Grieshop C.M., Flickinger E.A., Fahey G.C. Oral administration of arabinogalactan affects immune status and fecal microbial populations in dogs // Journal of Nutrition. 2002. V. 132. №. 3. P.478–482.</mixed-citation><mixed-citation xml:lang="en">Grieshop C.M., Flickinger E.A., Fahey G.C. Oral administration of arabinogalactan affects immune status and fecal microbial populations in dogs. Journal of Nutrition. 2002. vol. 132. no. 3. pp. 478–482.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Groman E.V., Enriquez P.M., Jung Chu, Josephson L. Arabinogalactan for hepatic drug delivery // Bioconjugate Chem. 1994. № 5. P. 547–556.</mixed-citation><mixed-citation xml:lang="en">Groman E.V., Enriquez P.M., Jung Chu, Josephson L. Arabinogalactan for hepatic drug delivery. Bioconjugate Chem. 1994. no. 5. pp. 547–556.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Sajjad A. Chitosan as a Flocculant: An Approach to Improve its Solubility for Efficient Harvesting of Microalgae // Korean Chemical Engineering Research. 2017. V. 55. №. 4. P. 530–534.</mixed-citation><mixed-citation xml:lang="en">Sajjad A. Chitosan as a Flocculant: An Approach to Improve its Solubility for Efficient Harvesting of Microalgae. Korean Chemical Engineering Research. 2017. vol. 55. no. 4. pp. 530–534.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Тихомирова Н.А. Продукты функционального питания // Молочная промышленность. 2013. №. 6. С. 46-49.</mixed-citation><mixed-citation xml:lang="en">Tikhomirova N.A. Functional food products. Dairy industry. 2013. no. 6. pp. 46-49. (in Russian).</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
