vguitВестник Воронежского государственного университета инженерных технологийProceedings of the Voronezh State University of Engineering Technologies2226-910X2310-1202VSUET10.20914/2310-1202-2023-1-54-63vguit-3179Research ArticleПищевая биотехнологияFood biotechnologyФизиологическая роль катехинов зеленого чаяThe physiological role of green tea catechinshttps://orcid.org/0000-0001-7183-6647СоболеваО. А.SobolevaO. A.

ведущий инженер-технолог, лаборатория цитогенетики, пр. Советский, 18, г. Кемерово, 650000, Россия

leading engineer, laboratory of cytogenetics, Sovetsky av., 18, Kemerovo, 650000, Russia

soboleva.olga88@ya.ruhttps://orcid.org/0000-0003-3485-9123МининаВ. И.MininaV. I.

д.б.н., профессор кафедры генетики и фундаментальной медицины, ул. Красная, 6, г. Кемерово, 650043, Россия

Dr. Sci. (Biol.), professor, genetics and fundamental medicine department, Krasnaya st., 6, Kemerovo, 650043, Russia

vminina@mail.ruhttps://orcid.org/0000-0001-6362-7589ВоробьеваЕ. Е.VorobyevaE. E.

магистрант, кафедра бионанотехнологии, ул. Красная, 6, г. Кемерово, 650043, Россия

master student, bionanotechnology department, Krasnaya st., 6, Kemerovo, 650043, Russia

89515923860k@gmail.comМилентьеваИ. С.MilentyevaI. S.

к.т.н., доцент, кафедра бионанотехнологии, ул. Красная, 6, г. Кемерово, 650043, Россия

Cand. Sci. (Engin.), associate professor, bionanotechnology department, Krasnaya st., 6, Kemerovo, 650043, Russia

irazumnikova@mail.ruhttps://orcid.org/0000-0002-5841-6311АстафьеваЕ. А.AstafevaE. A.

ассистент, кафедра морфологии и судебной медицины, ул. Ворошилова, 22а, г. Кемерово, 650056, Россия

assistant, morphology and forensic department, Voroshilova St., 22а, Kemerovo, 650056, Russia

astafeva.evgenia@ya.ruФедеральный исследовательский центр угля и углехимии СО РАНРоссияThe Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of SciencesRussian FederationКемеровский государственный университетRussian FederationKemerovo State UniversityRussian FederationКемеровский государственный медицинский университет Минздрава РФRussian FederationKemerovo State Medical UniversityRussian Federation2023010220238515463Copyright © Соболева О.А., Минина В.И., Воробьева Е.Е., Милентьева И.С., Астафьева Е.А., 20232023Соболева О.А., Минина В.И., Воробьева Е.Е., Милентьева И.С., Астафьева Е.А.Soboleva O.A., Minina V.I., Vorobyeva E.E., Milentyeva I.S., Astafeva E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.vestnik-vsuet.ru/vguit/article/view/3179

Зеленый чай – один из самых популярных напитков, потребляемых в мире. Важными компонентами, содержащимися в зеленом чае и обладающие антиоксидантными и антиканцерогенными свойствами, являются катехины – органические вещества, относящиеся к классу полифенольных соединений. Главным образом в зеленом чае содержатся 4 основных катехина: (-)-эпикатехин, (-)-эпикатехин-3-галлат, (-)-эпигаллокатехин и (-)-эпигаллокатехин-3-галлат. В данном обзоре обобщены результаты основных исследований, выполненных преимущественно за последние 5 лет, в которых приводятся доказательства, что катехины, содержащиеся в зеленом чае, защищают от ультрафиолетового излучения, способны улучшить качество жизни пациентов, страдающих онкологическими, сердечно-сосудистыми, нейродегенеративными, вирусными, инфекционными заболеваниями, ожирением и рядом других патологий, а также служить мерой профилактики данных заболеваний у здоровых индивидуумов. Показано, что самым мощным катехином, содержащимся в зеленом чае, является (-)-эпигаллокатехин-3-галлат. Описаны антиканцерогенные эффекты (-)-эпигаллокатехин-3-галлата в случае возникновения рака простаты, рака молочной железы, колоректального рака. Мощная антиоксидантная активность катехинов может лечь в основу профилактики развития инфекционных и вирусных заболеваний, а также улучшить качество жизни пациентов с метаболическим синдромом и ожирением. Таким образом, зеленый чай является не только тонизирующим напитком, но и важным средством профилактики и лечения заболеваний человека, в патогенезе которых важную роль играет свободнорадикальное окисление и оксидативный стресс. Сферами практического применения катехинов зеленого чая может быть терапия злокачественных опухолей (во время курса лучевой или химиотерапии), лечение вирусных, инфекционных, сердечно-сосудистых и нейродегенеративных заболеваний, защита кожи от действия ультрафиолетовых лучей и проч.

Green tea is one of the most popular drinks consumed in the world. Important components contained in green tea and having antioxidant and anticarcinogenic properties are catechins - organic substances belonging to the class of polyphenolic compounds. Green tea contains 4 main catechins: (-)-epicatechin, (-)-epicatechin-3-gallate, (-)-epigallocatechin and (-)-epigallocatechin-3-gallate. This review summarizes the results of key studies, predominantly performed over the last 5 years, which provide evidence that catechins in green tea protect against ultraviolet radiation, can improve the quality of life of patients suffering from cancer, cardiovascular, neurodegenerative, viral, infectious diseases, obesity and a number of other pathologies, as well as serve as a measure for the prevention of these diseases in healthy individuals. The most potent catechin found in green tea has been shown to be (-)-epigallocatechin-3-gallate. The anticarcinogenic effects of (-)-epigallocatechin-3-gallate in the case of prostate cancer, breast cancer, colorectal cancer are presented. The powerful antioxidant activity of catechins can form the basis for the prevention of the development of infectious and viral diseases, as well as improve the quality of life of patients with metabolic syndrome and obesity. Thus, green tea is not only a tonic drink, but also an important tool for the prevention and treatment of human diseases, in the pathogenesis of which free radical oxidation and oxidative stress play an important role. The areas of practical application of green tea catechins can be the treatment of malignant tumors (during a course of chemotherapy or radiation therapy), the treatment of viral, infectious and cardiovascular diseases, skin protection from ultraviolet rays, etc.

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The authors declare that there are no conflicts of interest present.