vguitВестник Воронежского государственного университета инженерных технологийProceedings of the Voronezh State University of Engineering Technologies2226-910X2310-1202VSUET10.20914/2310-1202-2026-1-306-315vguit-3772Research ArticleХимическая технологияFundamental and Applied chemistry, chemical technologyПолучение и свойства двухслойных полиэлектролитных пленок на основе хитозана и гиалуроната натрия.Obtaining and Properties of Bi-layer Polyelectrolyte Films Based on Chitosan and Sodium Hyaluronatehttps://orcid.org/0009-0000-3691-2544ГлебскаяС. А.GlebskaiaS. A.glebskaia@itmo.ruhttps://orcid.org/0009-0004-1170-8036ГрибиниченкоТ. Н.GribinichenkoT. N.tngribinichenko@itmo.ruhttps://orcid.org/0009-0002-4906-0787ДавлетшинаМ. С.DavletshinaM. S.2006vfienrf2006@mail.ruhttps://orcid.org/0009-0007-1169-0405ДоронинаА. Д.DoroninaA. D.annadoronina1218@mail.ruhttps://orcid.org/0000-0003-2510-2639УспенскаяМ. В.UspenskayaM. V.mv_uspenskaya@mail.ruhttps://orcid.org/0000-0002-6894-1224ОлехновичР. О.OlekhnovichR. O.r.o.olekhnovich@mail.ruНациональный исследовательский университет ИТМОITMO UniversityСанкт-Петербургский государственный университетSaint Petersburg State University202601042026881306315Copyright © Глебская С.А., Грибиниченко Т.Н., Давлетшина М.С., Доронина А.Д., Успенская М.В., Олехнович Р.О., 20262026Глебская С.А., Грибиниченко Т.Н., Давлетшина М.С., Доронина А.Д., Успенская М.В., Олехнович Р.О.Glebskaia S.A., Gribinichenko T.N., Davletshina M.S., Doronina A.D., Uspenskaya M.V., Olekhnovich R.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.vestnik-vsuet.ru/vguit/article/view/3772

В работе представлена методика получения двухслойных плёнок на основе полиэлектролитного комплекса гиалуроната натрия и хитозана, ориентированных на применение в биомедицинских целях. Изучено влияние массового соотношения компонентов, последовательности нанесения слоёв и толщины плёночного материала на структуру, морфологию и механические свойства получаемых плёнок. Формирование полиэлектролитного комплекса подтверждено методом ИК-Фурье спектроскопии, выявившим характерные изменения полос поглощения функциональных групп полимеров. В ходе работы определены морфологические характеристики полученных полимерных плёнок методом оптической микроскопии и физико-механические характеристики при растяжении. Показано, что оптимальные свойства плёночного материала достигаются при массовом соотношении гиалуроновой кислоты и хитозана 1:7 и последовательности нанесения слоёв HA-Na → CH. Установлено, что увеличение толщины плёнки за счёт повышения объёма наносимых слоев приводит к существенному росту прочностных характеристик и относительного удлинения. Полученные результаты свидетельствуют о возможности целенаправленного регулирования свойств двухслойных плёнок на основе гиалуроната натрия и хитозана путём варьирования технологических параметров, что делает разработанные материалы перспективными для использования в качестве биомедицинских плёночных матриксов при травмах и повреждениях.

In this study, a method for preparing bilayer films based on a polyelectrolyte complex of sodium hyaluronate and chitosan is presented, with a view toward biomedical applications. The effects of the component mass ratio, layer deposition sequence, and film thickness on the structure, morphology, and mechanical properties of the resulting films were investigated. Formation of the polyelectrolyte complex was confirmed by FTIR spectroscopy, which revealed characteristic changes in the absorption bands of the polymers’ functional groups. The morphological features of the polymer films were evaluated by optical microscopy, and tensile testing was used to determine their mechanical performance. The optimal film properties were achieved at a hyaluronic acid (HA-Na) to chitosan (CH) mass ratio of 1:7 and a layer deposition sequence of HA-Na → CH. Increasing film thickness by increasing the volume of the deposited layers resulted in a pronounced improvement in tensile strength and elongation at break. Overall, the findings demonstrate that the properties of sodium hyaluronate/chitosan bilayer films can be purposefully tuned by varying processing parameters, making these materials promising biomedical film matrices for the treatment of injuries and tissue damage. 

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The authors declare that there are no conflicts of interest present.