Development of theoretical and practical bases of technology of biocompatible materials of a domestic production on the basis of the natural polymeric systems allocated from raw materials of an animal, fish and a phytogenesis is actual in interests of development of science, health care, ecology. Now practically there are no domestic materials on the basis of products of modification of biopolymers for production of biocompatible materials with adjustable physical and chemical and biological properties. In this regard the special importance is gained by works on studying of functional properties of natural biopolymers, in particular collagen, elastin, hyaluronic acid. Interest of researchers to biopolymers of the proteinaceous nature is quite reasonable as they possess sufficient permeability, a big specific surface and sorption capacity, possibility of receiving convenient in technological forms, a low immunogenicity, possibility of regulation лизиса. Data on possible ways of use are presented in article secondary the collagenic wastes - skins of fishes of internal reservoirs of Russia. Innovative processing methods of processing of secondary raw materials with receiving functional biopolymers of a wide range of application are developed. With application of modern methods of researches their characteristics and property are defined. On a complex of organoleptic, physical and chemical indicators, indexes of biological activity the received preparations hyaluronic acid and collagen can find broad application in medicine, cosmetology. The resource-saving technology of receiving tanning semi-finished products easily giving in to further processing for the purpose of receiving leather haberdashery and textile production is developed. Thus, scientific new approaches in processing of skins of pond fishes on the basis of their deep processing are proved.