The study of the effect of experimental soft drinks based on tomato supernatants on the morphofunctional state of the internal organs of healthy sexually mature white outbred Wistar rats was conducted at the Federal State Budgetary Scientific Institution "ALL-Russian scientific research veterinary institute of pathology, pharmacology and therapy" (g. Voronezh) and Federal State Budget Educational Institution of Higher Education "Voronezh State University of Engineering Technologies". The aim of the study was to study how tomato supernatants affect the morphofunctional state of the kidneys, liver, duodenal mucosa and duodenal villi. For this purpose, four groups of animals were formed. The first group was given a drink based on a supernatant from tomato juice of the Volgogradsky 5/95 variety, the second group was given a drink based on a supernatant from tomato juice of the Orange variety, and the third group was given a drink based on a supernatant from tomato juice of the Black Prince variety. A control group was also formed, the animals of which received the usual diet. Morphological parameters of organs were studied using generally accepted diagnostic methods. As a result of histological and morphometric studies, various morphological changes were found in the first and second groups of patients. In particular, granularity of the cytoplasm of hepatocytes, foci of infiltration, detachment of the villi epithelium and a decrease in the length of villi in the intestine were observed. Although these changes are not serious and reversible, they can negatively affect the animal's body and require correction. At the same time, no changes were found in the organs of animals of the third group and the control group, which may indicate the absence of negative effects detected in the first and second groups of animals.

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