The development of the food industry in combination with a change in the structure of nutrition and energy consumption of the body led to the creation of new directions. So, to solve the problems of reducing losses from socially significant diseases, personalized nutrition can be used. In particular, in personalized nutrition, food additives (PD) can be used as food enrichers that give them functional properties. Biologically active food additives can be considered as independent products that activate certain processes in the body, having regulatory properties. The article is devoted to the prospects in the field of creating food additives and biologically active food additives for personalized nutrition. The study applied theoretical research methods (meta-analysis) based on PRISMA. The selection of scientific achievements was carried out on the Google Scholar platform for search queries "omix approaches," "food additives," "promising technologies," "application efficiency," "personalized nutrition" with a time span of 5 years from 2020 to 2024. It was revealed that research is underway both in relation to the effect of food additives and dietary supplements and their components on focus groups (for example, athletes), and laboratory animals. Separate studies are devoted to the effect of technological steps on the effectiveness of the biological activity of the product. According to existing ideas, the following can be included in the scheme of the stages of development of food additives and dietary supplements: the choice of target pathology; target effect of the developed product; concretizing the selected effect; selection of a nutraceutical candidate; selection of the best combination; conducting bioavailability studies; animal testing; human testing to establish dosage; determination of shelf life. Omix approaches can be applied at the stage of choosing the target pathology (through the marker gene), with which the developed supplement will work. Omix approaches in order to implement personalized nutrition can change the structure of the development of supplement technologies, used for the evidence base of the effectiveness and safety of supplements, excluding testing on animals with the chosen preventive effect.