Bacteria and bifidogenic drugs became more popular for animal’s treatment. The results of studying bacterial polycomponent symbiotic substance (PCBSS) effect on productive indicators of pigs with intensive cultivation technology was presented. Zootechnical, clinical, hematological, morphological, physico-chemical, research methods were used in experimental part. The effect of three and four course treatment with polycomponent bacterial symbiotic substance (PCBSS) was established. The lyophilized cells of lacto- and bifidobacteria Bifidobacterium bifidum and Lactobacillus bulgaricus was included in this drug. Due to this treatment the reduction of endogenous intoxication by metabolites of various genesis and normalization of the activity of marker transaminases, protein metabolism, activation of energy processes, increase digestibility of feed and increase animals mass were observed. To the moment of animals butchering the average mass of animals after 3 and 4 courses PKBSS exceeded the weight of animals in the control group by 7 kg (5.2%) and 10.7 (7.9%), respectively. The digestibility of dry matter feed by 3% was increased by PCBSS addition to the animals diet. The safety of pigs in the experimental groups was higher compared with the control by 3.4-17.5%. Due to the digestion of crude protein the digestion of organic matter was increased in experimental pigs groups. By leukocyte analysis in blood it was shown that use of PCBSS had a stimulating effect on the formation of white blood cells. At the end of the experiment it was found that for animals of the experimental groups the level of total blood protein was higher than in the control group by 0.66% and by 3.77%. Decreasing in the activity of marker transaminases: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, lactate dehydrogenase (LDH) was observed in experimental groups. The intestinal microbiota with its exogenous correction by PCBSS regulates the physiological processes of the animal, and this was confirmed by an increasing of animals body weight and changes in the biochemical reactions, by decreasing in mortality and by increasing in feed digestibility.

bifidobacteria, lactobacilli, feed digestibility, natural resistance, pigs

1. Zabashta N.N., Golovko E.N., Koshchaev A.G. Probiotic, prebiotic and synbiotic in the diet of pigs for organic pork. Vestnik APK Stavropol'ya [Bulletin of the APK of Stavropol]. 2017. no. 2. pp. 84–89. (in Russian).

2. Kononenko S.I. Actual problems of the organization of feeding in modern conditions. Politematicheskij setevoj ehlektronnyj nauchnyj zhurnal Kubanskogo gosudarstvennogo agrarnogo universiteta [Polythematic network electronic scientific journal of the Kuban State Agrarian University]. 2016. no. 115. (in Russian).

3. Kononenko S.I., Pskhacieva Z.V., Yurina N.A., Yurin D.A. Pork production using complexes of dietary supplements. Razvitie pishchevoj i pererabatyvayushchej promyshlennosti Rossii: kadry i nauka [Scientific conference with international participation "The development of food and processing industry in Russia: personnel and science." Part 3]. Moscow, Moscow University of Food Industry, 2017. pp. 36. (in Russian).

4. Korobov D.V., Pohodnya G.S. The effectiveness of fattening pigs with the introduction in their diet of probiotic "Gidrolaktiv". Problemy i resheniya sovremennoj agrarnoj ehkonomiki [Problems and solutions of the modern agrarian economy]. 2017. pp. 27–28. (in Russian).

5. Osnovy polnocennogo kormleniya svinej [Basics of full feeding pigs]. Dnepropetrovsk, Art Press, 2000. 360 p. (in Russian).

6. Hochenkov A.A., SHamonina A.I., Dzhumkova M.V., Tanana L.A. Parameters of quality and safety of pork produced under industrial technology. Aktual'nye problemy intensivnogo razvitiya zhivotnovodstva [Actual problems of intensive development of livestock]. 2015. no. 1. pp. 180–195. (in Russian).

7. Dowarah R., Verma A.K., Agarwal N., Patel B.H.M. et al. Effect of swine based probiotic on performance, diarrhoea scores, intestinal microbiota and gut health of grower-finisher crossbred pigs. Livestock Science. 2017. vol. 195. pp. 74–79.

8. He Y., Mao C., Wen H., Chen Z. et al. Influence of ad libitum feeding of piglets with Bacillus subtilis fermented liquid feed on gut flora, luminal contents and health. Scientific reports. 2017. vol. 7. pp. 44553.

9. Conly J. Antimicrobial resistance in Canada. Canadian Medical Association Journal. 2002. vol. 167. pp. 885–891.

10. Kritas S.K. Probiotics and Prebiotics for the Health of Pigs and Horses. Probiotics and Prebiotics in Animal Health and Food Safety. Springer. 2018. pp. 109–126.

11. Lan R., Tran H., Kim I. Effects of probiotic supplementation in different nutrient density diets on growth performance, nutrient digestibility, blood profiles, fecal microflora and noxious gas emission in weaning pig. Journal of the Science of Food and Agriculture. 2017. vol. 97. no. 4. pp. 1335–1341.

12. Liu W., Devi S., Park J., Kim I. Effects of complex probiotic supplementation in growing pig diets with and without palm kernel expellers on growth performance, nutrient digestibility, blood parameters, fecal microbial shedding and noxious gas emission. Animal Science Journal. 2018. vol. 89. no 3. pp. 552–560.

13. Yang J., Qian K., Wang C., Wu Y. Roles of Probiotic Lactobacilli Inclusion in Helping Piglets Establish Healthy Intestinal Inter-environment for Pathogen Defense. Probiotics and antimicrobial proteins. 2018. vol. 10. no 2. pp. 243–250.

14.