Preview

Proceedings of the Voronezh State University of Engineering Technologies

Advanced search

Study of physicochemical properties of sublimated metabiotic food system

https://doi.org/10.20914/2310-1202-2026-1-13-18

Abstract

Metabiotic food systems are a complex of non-viable probiotic microorganisms and products of their lifetime metabolism, which maintain stability in a wide range of рН and temperature values. At the same time, sublimated metabiotic substances have suboptimal physicochemical characteristics associated with high hygroscopicity, unsatisfactory flowability, which complicates the industrial use of these systems. In order to justify the use of sublimated metabiotic substance in the technology of solid forms and for its further use in the development and production of new biologically active substances, specialized, including dietary, food products, physicochemical and technological characteristics were studied. Analysis of the flow and angle of repose parameters showed suboptimal values for the studied metabiotic food form, the numerical values of the studied parameters were 2,6 g/s and 35 and 57,5 degrees, the moisture content corresponded to 14,99%. Based on the sieve analysis data, it was established that the lyophilized metabiotic substance under study is heterogeneous, the degree of grinding varies from medium to very small, which is confirmed by low flowability indicators. The calculated Hausner and Carr coefficients for the metabiotic substance were 2,35 and 57,45, indicating insufficient attraction and adhesion under pressure. As a result of experimental tests, it was established that the substance under study has suboptimal technological properties, which determines the feasibility of using wet granulation technology for the development of rational forms and subsequent use in the food industry.

About the Authors

S. I. Vasilyeva
Voronezh State University

Cand. Sci. (Ph.), assistant professor, department of pharmaceutical technology, University Square, 1 Voronezh, 394018, Russia



M. S. Bondar
Voronezh State University

assistant, department of pharmaceutical technology, University Square, 1 Voronezh, 394018, Russia



E. A. Pozhidaeva
Voronezh State University of Engineering Technologies

Cand. Sci. (Engin.), assistant professor, department of animal products technology, Revolution Av., 19 Voronezh, 394036, Russia



E. S. Popov
Voronezh State University of Engineering Technologies

Dr. Sci. (Engin.), professor, service and restaurant business department, Revolution Av., 19 Voronezh, 394036, Russia



Y. A. Dymovskikh
Voronezh State University of Engineering Technologies

graduate student, service and restaurant business department, Revolution Av., 19 Voronezh, 394036, Russia



Y. V. Durova
Voronezh State University of Engineering Technologies

student, service and restaurant business department, Revolution Av., 19 Voronezh, 394036, Russia



References

1. Salminen S., Collado M.C., Endo A. et al. The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nature Reviews Gastroenterology & Hepatology. 2021. vol. 18. no. 9. pp. 649–667.

2. Sabahi S., Homayouni Rad A., Aghebati-Maleki L. et al. Postbiotics as the new frontier in food and pharmaceutical research. Critical Reviews in Food Science and Nutrition. 2023. vol. 63. no. 26. pp. 8375–8402.

3. Rad A.H., Aghebati-Maleki L., Kafil H.S. et al. Potential pharmaceutical and food applications of postbiotics: A review. Current Pharmaceutical Biotechnology. 2020. vol. 21. no. 15. pp. 1576–1587. doi: 10.2174/1389201021666200516154833

4. Zhao X., Zhang F., Chen Z. et al. Unlocking the power of postbiotics: A revolutionary approach to nutrition for humans and animals. Cell Metabolism. 2024. vol. 36. no. 4. pp. 725–744.

5. Maftei N.M., Bujor A.I., Cojocaru D. et al. The potential impact of probiotics on human health: an update on their health-promoting properties. Microorganisms. 2024. vol. 12. no. 2. p. 234. doi: 10.3390/microorganisms12020234

6. Fuochi V., Furneri P.M. Applications of probiotics and their potential health benefits. International Journal of Molecular Sciences. 2023. vol. 24. no. 21. p. 15915. doi: 10.3390/ijms242115915

7. Hijova E. Postbiotics as metabolites and their biotherapeutic potential. International Journal of Molecular Sciences. 2024. vol. 25. no. 10. p. 5441. doi: 10.3390/ijms25105441

8. Zhou P., Yang D., Zhang B. et al. Recent advances and potentiality of postbiotics in the food industry: Composition, inactivation methods, current applications in metabolic syndrome, and future trends. Critical Reviews in Food Science and Nutrition. 2024. vol. 64. no. 17. pp. 5768–5792. doi: 10.1080/10408398.2022.2158174

9. Shakoor R., Wang T., Zhang Y. et al. Novel strategies for extraction, purification, processing, and stability improvement of bioactive molecules. Journal of Basic Microbiology. 2023. vol. 63. no. 3-4. pp. 276–291. doi: 10.1002/jobm.202200401

10. Prajapati N., Kathad U., Sheth N. et al. Postbiotic production: Harnessing the power of microbial metabolites for health applications. Frontiers in Microbiology. 2023. vol. 14. p. 1306192. doi: 10.3389/fmicb.2023.1306192

11. Mishra B., Kumar R., Sahu A.R. et al. Postbiotics: The new horizons of microbial functional bioactive compounds in food preservation and security. Food Production, Processing and Nutrition. 2024. vol. 6. p. 56. doi: 10.1186/s43014-023-00200-w

12. Liu C., Liu Z., He Y. et al. From probiotics to postbiotics: Concepts and applications. Animal Research and One Health. 2023. vol. 1. no. 1. pp. 92–114. doi: 10.1002/aro2.7

13. Liang B., Xing D. The current and future perspectives of postbiotics. Probiotics and Antimicrobial Proteins. 2023. vol. 15. no. 6. pp. 1626–1643. doi: 10.1007/s12602-023-10045-x

14. Liu H., Chen W., Zhang W. et al. Progress on Research and Application of Postbiotics. Food Science. 2024. vol. 45. no. 1. pp. 326–333. doi: 10.7506/spkx1002-6630-20221229-272

15. Meena K.K., Sharma S., Sharma M. et al. Comprehensive insights into postbiotics: Bridging the gap to real-world application. Food & Nutrition. 2025. vol. 1. no. 2. p. 100024. doi: 10.1016/j.fnutr.2025.100024

16. Sorokin O.V., Ilyina A.V., Smirnov V.V. Biological activity and therapeutic potential of metabiotics. Scientific Notes of V.I. Vernadsky Crimean Federal University. Biology. Chemistry. 2025. vol. 11. no. 2. pp. 224–236. (in Russian)

17. Eselevich R.V., Surov D.A., Gerasimov D.G. et al. Comparative assessment of metabiotic compositions and their indications for use in patients in acute and chronic critical conditions. Polytrauma. 2024. no. 4. pp. 75–84. (in Russian)

18. Tkachenko E.I., Dadali V.A. Metabiotics — a new direction for effective prevention and treatment of diseases. Experimental and Clinical Gastroenterology. 2023. no. 12 (220). pp. 4–18. (in Russian)

19. Speckmann B., Vulevic J., Klinder A. et al. Exploring substrate–microbe interactions: a metabiotic approach toward developing targeted synbiotic compositions. Gut Microbes. 2024. vol. 16. no. 1. p. 2305716.

20. Aragón-Rojas S., Quintanilla-Carvajal M.X., Hernández-Sánchez H. Sublimation conditions as critical factors during freeze-dried probiotic powder production. Drying Technology. 2020. vol. 38. no. 3. pp. 333–349.

21. Fan L., Wang Y., Xu X. et al. Effects of different drying methods on the physicochemical properties, antioxidant activity and gut microbiota fermentation behaviours of polysaccharides from Schizophyllum commune. Food Research International. 2025. vol. 200. p. 118000.

22.


Review

For citations:


Vasilyeva S.I., Bondar M.S., Pozhidaeva E.A., Popov E.S., Dymovskikh Y.A., Durova Y.V. Study of physicochemical properties of sublimated metabiotic food system. Proceedings of the Voronezh State University of Engineering Technologies. 2026;88(1):13-18. (In Russ.) https://doi.org/10.20914/2310-1202-2026-1-13-18

Views: 200

JATS XML


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2226-910X (Print)
ISSN 2310-1202 (Online)