QUANTUM-CHEMICAL MODEL OF THYROID HORMONES AS ELECTRON DONOR AND ELECTRON CARRIERS
https://doi.org/10.20914/2310-1202-2013-4-179-184
Abstract
A new mechanism of interaction of thyroid gland hormones with biotargets is offered on the basis of X-ray structural data from Protein Data Base and quantum-chemical computation of 3,3',5'-triiodothyronine (T 3 ) interaction with the active center of thyroidal receptor as well as with oxygen molecules and ATP. The nature of the mechanism is that when T 3 and T 4 interact with biotargets, a transportation of electron occurs, and T 3 and T 4 can act as donors and acceptors of electron. Being electron carriers, T 3 and T 4 can interact with molecules that are in triplet state (O 2 , ATP, thyroidal receptor).
About the Authors
N. B. Kuznetsova
Курский государственный университет
Russian Federation
Russian Federation
P. E. Kuznetsov
Курский государственный университет
Russian Federation
Russian Federation
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Review
For citations:
Kuznetsova N.B., Kuznetsov P.E. QUANTUM-CHEMICAL MODEL OF THYROID HORMONES AS ELECTRON DONOR AND ELECTRON CARRIERS. Proceedings of the Voronezh State University of Engineering Technologies. 2013;(4):179-184. (In Russ.) https://doi.org/10.20914/2310-1202-2013-4-179-184
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